Mathieu Desroches

External Scientific Member

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Information of interest

  • Interaction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β 

    Bourgade, K.; Frost, E.; Dupuis, G.; Witkowski, J.M.; Laurent, B.; Calmettes, C.; Ramassamy, C.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Fülöp, T. (2022-09-19)
    Background: Unravelling the mystery of Alzheimer's disease (AD) requires urgent resolution given the worldwide increase of the aging population. There is a growing concern that the current leading AD hypothesis, the amyloid ...
  • A phenomenological model for interfacial water near hydrophilic polymers 

    Earls, A.; Calderer, M.-C.; Desroches, M.Autoridad BCAM; Zarnescu, A.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2022-06-30)
    We propose a minimalist phenomenological model for the ‘interfacial water’ phenomenon that occurs near hydrophilic polymeric surfaces. We achieve this by combining a Ginzburg–Landau approach with Maxwell’s equations which ...
  • Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change 

    Fülöp, T.; Larbi, A.; Pawelec, G.; Cohen, A.; Provost, G.; Khalil, A.; Lacombe, G.; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Hirokawa, K.; Franceschi, C.; Witkowski, J.M. (2022-04-01)
    Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as ...
  • Classification of bursting patterns: A tale of two ducks 

    Desroches, M.Autoridad BCAM; Rinzel, J.; Rodrigues, S.Autoridad BCAM (2022-01-20)
    Bursting is one of the fundamental rhythms that excitable cells can generate either in response to incoming stimuli or intrinsically. It has been a topic of intense research in computational biology for several decades. ...
  • Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease 

    Munawara, U.; Catanzaro, M.; Xu, W.; Tan, C.; Hirokawa, K.; Bosco, N.; Dumoulin, D.; Khalil, A.; Larbi, A.; Lévesque, S.; Ramassamy, C.; Barron, A.; Cunnane, S.; Beauregard, P.; Bellenger, J.P.; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Witkowski, J.M.; Laurent, B.; Frost, E.; Fülöp, T. (2021-12-01)
    Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related ...
  • Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease 

    Fülöp, T.; Tripathi, S.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Desroches, M.Autoridad BCAM; Bunt, T.; Eiser, A.; Bernier, F.; Beauregard, P.; Barron, A.; Khalil, A.; Plotka, A.; Hirokawa, K.; Larbi, A.; Bocti, C.; Laurent, B.; Frost, E.; Witkowski, J. (2021-05-04)
    Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
  • Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease 

    Fülöp, T.; Munawara, U.; Larbi, A.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM; Catanzaro, M.; Guidolin, A.; Khalil, A.; Bernier, F.; Barron, A.E.; Hirokawa, K.; Beauregard, P.B.; Dumoulin, D.; Bellenger, J.-P.; Witkowski, J.M.; Frost, E. (2020-05-26)
    Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
  • Metastable resting state brain dynamics 

    beim Graben, P.; Jimenez-Marin, A.; Diez, I.; Cortes, J.M.; Desroches, M.Autoridad BCAM; Rodrigues, S.Autoridad BCAM (2019-09-06)
    Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
  • Anticipation via canards in excitable systems 

    Köksal Ersöz, E.; Desroches, M.Autoridad BCAM; Mirasso, C.; Rodrigues, S.Autoridad BCAM (2019-01-14)
    Neurons can anticipate incoming signals by exploiting a physiological mechanism that is not well understood. This article offers a novel explanation on how a receiver neuron can predict the sender’s dynamics in a ...

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