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+34 946 567 842
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+34 946 567 842
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mdesroches@bcamath.org
Information of interest
- Orcid: 0000-0002-9325-4207
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Dynamical System Modeling in Schizophrenia: A Narrative Review of Computational Psychiatry Frameworks
Soydemir, H.; Gauld, C.; Desroches, M.
; Pignon, B.; Depannemaecker, D. (2026-08-18)
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Biophysically inspired mean-field model of neuronal populations driven by ion exchange mechanisms
Rabuffo, Giovanni; Bandyopadhyay, Abhirup; Calabrese, Carmela; Gudibanda, Kashyap; Depannemaecker, Damien; Mitiko Takarabe, Lavinia; Chatterjee, Sourin; Saggio, Maria Luisa; Desroches, M.; Ivanov, Anton; Linne, Marja-Leena; Bernard, Christophe; Petkovski, Spase; Jirsa, Viktor K (2026-05-28)
Whole-brain simulations are a valuable tool for gaining insight into the multiscale processes that regulate brain activity. Due to the complexity of the brain, it is impractical to include all microscopic details in a ...
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Multiple bursting patterns in lateral habenula neurons: Experiments and computational model
Fedorov, Dmitry; Campillo, Fabien; Desroches, M.; Soria-Gómez, Edgar; Rodrigues, S.; Piriz, Joaquin (2026-04-02)
Abstract: The lateral habenula (LHb) is a small brain structure specialized in encoding aversive signals. Elevated bursting in the LHb has been linked to depressive-like behaviours in animal models. Bursting is a complex ...
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Complex excitability and “flipping" of granule cells: An experimental and computational study
Danielewicz, J.; Girier, Guillaume; Chizhov, Anton; Desroches, M.; Encinas, Juan Manuel; Rodrigues, S. (2026-02-02)
In response to prolonged depolarizing current steps, different classes of neurons display specific firing characteristics (i.e., excitability class), such as a regular train of action potentials with more or less adaptation, ...
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Unmasking the hidden catalyst: How infections trigger Alzheimer’s disease
Fülöp, Tamas; Cohen, Alan A; Frost, Eric H; Lévesque, Simon; Khalil, Abdelouaed; Rodrigues, S.; Desroches, M.; Alami, Mehdi; Berrougui, Hicham; Ramassamy, Charles; Hirokawa, Katsuiku; Witkowski, Jacek M; Laurent, Benoît (2026-01-27)
For years, the understanding of Alzheimer's disease (AD) has been shaped by the amyloid hypothesis, which suggests that pathological markers like amyloid-β (Aβ) and phosphorylated tau are the primary drivers of the disease. ...
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Growing order-heterogeneous simplicial complexes
Ding, Mengjun; Yu, Jia; Barros de Souza, D.; Rodrigues, S.; Desroches, M.; Li, Chunbo; Sun, Weiqiang (2026-01-26)
Complex systems are commonly modeled using graphs, where nodes represent entities and edges represent pairwise interactions. Yet, many real-world systems exhibit higher-order interactions that involve multiple entities ...
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Observing hidden neuronal states in experiments
Amakhin, Dmitry; Chizhov, Anton; Girier, Guillaume; Desroches, M.; Sieber, Jan; Rodrigues, S. (2025-12-08)
In this article we demonstrate a general protocol for constructing systematically experimental steady-state bifurcation diagrams for electrophysiologically active cells. We perform our experiments on entorhinal cortex ...
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Depolarization block induction via slow NaV1.1 inactivation in Dravet syndrome
Lemaire, L.; Desroches, M.; Rodrigues, S.; Campillo, F. (2025-08-25)
Dravet syndrome is a developmental and epileptic encephalopathy, characterized by the early onset of drug-resistant seizures and various comorbidities. Most cases of this severe and complex pathology are due to mutations ...
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The role of gap junctions and clustered connectivity in emergent synchronisation patterns of inhibitory neuronal networks
Todd, H.; Desroches, M.; Cayco-Gajic, A.; Gutkin, B.; Gutkin (2025-05-08)
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GABAergic neurons can facilitate the propagation of cortical spreading depolarization: experiments in mouse neocortical slices and a novel neural field computational model
Baspinar, E.; Simonti, M.; Srour, H.; Desroches, M.; Avitabile, D.; Mantegazza, M. (2025-04-29)
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Modeling impairment of ionic regulation with extended Adaptive Exponential integrate-and-fire models
Depannemaecker, D.; Tesler, F.; Desroches, M.; Jirsa, V.; Destexhe, A. (2025-03-01)
To model the dynamics of neuron membrane excitability many models can be considered, from the most biophysically detailed to the highest level of phenomenological description. Recent works at the single neuron level have ...
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Discontinuity-Induced Dynamics in the Conductance-Based Adaptive Exponential Integrate-and-Fire Model
Desroches, M.; Kowalczyk, P.; Rodrigues, S. (2025-01-01)
In this article, we present a computational study of the Conductance-Based Adaptive Exponential (CAdEx) integrate-and-fire neuronal model, focusing on its multiple timescale nature, and on how it shapes its main dynamical ...
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Infection, neuroinflammation and interventions for healthy brain and longevity
Fülöp, T.; Ramassamy, C.; Lacombe, G.; Frost, E.; Cohen, A.; Rodrigues, S.; Desroches, M.; Hirokawa, K.; Laurent, B.; Witkowski, J.M. (2024-09-12)
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Slow–fast dynamics in a neurotransmitter release model: Delayed response to a time-dependent input signal
Sensi, M.; Desroches, M.; Rodrigues, S. (2023-12-01)
We propose a generalization of the neurotransmitter release model proposed in Rodrigues et al. (2016). We increase the complexity of the underlying slow–fast system by considering a degree-four polynomial as parametrization ...
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Geometry of spiking patterns in early visual cortex: A topological data analytic approach
Guidolin, A.; Desroches, M.; Victor, J. D.; Purpura, K. P.; Rodrigues, S. (2022-11-16)
In the brain, spiking patterns live in a high-dimensional space of neurons and time. Thus, determining the intrinsic structure of this space presents a theoretical and experimental challenge. To address this challenge, we ...
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Interaction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β
Bourgade, K.; Frost, E.; Dupuis, G.; Witkowski, J.M.; Laurent, B.; Calmettes, C.; Ramassamy, C.; Desroches, M.; Rodrigues, S.; Fülöp, T. (2022-09-19)
Background: Unravelling the mystery of Alzheimer's disease (AD) requires urgent resolution given the worldwide increase of the aging population. There is a growing concern that the current leading AD hypothesis, the amyloid ...
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A phenomenological model for interfacial water near hydrophilic polymers
Earls, A.; Calderer, M.-C.; Desroches, M.; Zarnescu, A.; Rodrigues, S. (2022-06-30)
We propose a minimalist phenomenological model for the ‘interfacial water’ phenomenon that occurs near hydrophilic polymeric surfaces. We achieve this by combining a Ginzburg–Landau approach with Maxwell’s equations which ...
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Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
Fülöp, T.; Larbi, A.; Pawelec, G.; Cohen, A.; Provost, G.; Khalil, A.; Lacombe, G.; Rodrigues, S.; Desroches, M.; Hirokawa, K.; Franceschi, C.; Witkowski, J.M. (2022-04-01)
Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as ...
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Classification of bursting patterns: A tale of two ducks
Desroches, M.; Rinzel, J.; Rodrigues, S. (2022-01-20)
Bursting is one of the fundamental rhythms that excitable cells can generate either in response to incoming stimuli or intrinsically. It has been a topic of intense research in computational biology for several decades. ...
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Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease
Munawara, U.; Catanzaro, M.; Xu, W.; Tan, C.; Hirokawa, K.; Bosco, N.; Dumoulin, D.; Khalil, A.; Larbi, A.; Lévesque, S.; Ramassamy, C.; Barron, A.; Cunnane, S.; Beauregard, P.; Bellenger, J.P.; Rodrigues, S.; Desroches, M.; Witkowski, J.M.; Laurent, B.; Frost, E.; Fülöp, T. (2021-12-01)
Background: Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related ...
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Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer’s Disease
Fülöp, T.; Tripathi, S.; Rodrigues, S.; Desroches, M.; Bunt, T.; Eiser, A.; Bernier, F.; Beauregard, P.; Barron, A.; Khalil, A.; Plotka, A.; Hirokawa, K.; Larbi, A.; Bocti, C.; Laurent, B.; Frost, E.; Witkowski, J. (2021-05-04)
Alzheimer’s disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease. The etiology of AD is not known but AD may be considered as a clinical syndrome with multiple ...
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Spike-adding and reset-induced canard cycles in adaptive integrate and fire models
Desroches, M.; Kowalczyk, P.; Rodrigues, S. (2021-05-03)
We study a class of planar integrate and fire (IF) models called adaptive integrate and fire (AIF) models, which possesses an adaptation vari- able on top of membrane potential, and whose subthreshold dynamics is piece- ...
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Why we should use topological data analysis in ageing: Towards defining the “topological shape of ageing”
Fülöp, T.; Desroches, M.; Cohen, A.; Santos, F.A.N.; Rodrigues, S. (2020-10-27)
Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be ...
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Inflection, Canards and Folded Singularities in Excitable Systems: Application to a 3D FitzHugh–Nagumo Model
Uria-Albizuri, J.; Desroches, M.; Krupa, M.; Rodrigues, S. (2020-09-07)
Specific kinds of physical and biological systems exhibit complex Mixed-Mode Oscillations mediated by folded-singularity canards in the context of slow-fast models. The present manuscript revisits these systems, specifically ...
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Targeting Infectious Agents as a Therapeutic Strategy in Alzheimer’s Disease
Fülöp, T.; Munawara, U.; Larbi, A.; Desroches, M.; Rodrigues, S.; Catanzaro, M.; Guidolin, A.; Khalil, A.; Bernier, F.; Barron, A.E.; Hirokawa, K.; Beauregard, P.B.; Dumoulin, D.; Bellenger, J.-P.; Witkowski, J.M.; Frost, E. (2020-05-26)
Alzheimer’s disease (AD) is the most prevalent dementia in the world. Its cause(s) are presently largely unknown. The most common explanation for AD, now, is the amyloid cascade hypothesis, which states that the cause of ...
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Metastable resting state brain dynamics
beim Graben, P.; Jimenez-Marin, A.; Diez, I.; Cortes, J.M.; Desroches, M.; Rodrigues, S. (2019-09-06)
Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state ...
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Anticipation via canards in excitable systems
Köksal Ersöz, E.; Desroches, M.; Mirasso, C.; Rodrigues, S. (2019-01-14)
Neurons can anticipate incoming signals by exploiting a physiological mechanism that is not well understood. This article offers a novel explanation on how a receiver neuron can predict the sender’s dynamics in a ...
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Conductance-Based Refractory Density Approach for a Population of Bursting Neurons
Chizhov, A.; Campillo, F.; Desroches, M.; Guillamon A; Rodrigues, S. (2019)
The conductance-based refractory density (CBRD) approach is a parsimonious mathematical-computational framework for modeling interact- ing populations of regular spiking neurons, which, however, has not been yet extended ...