Marina Echeverriak bere tesia defendatuko du irailaren 14an, astelehenean

Defentsa Leioako Zientzia eta Teknologia Fakultateko Adela Moyua Aretoan izango da, 11:30ean.

Marina Matematikako doktore ikertzailea da Euskal Herriko Unibertsitatean (EHU). 2019ko irailean sartu zen BCAMen, garai hartan Biozientzietako Modelizazio Matematikoko taldea zenaren parte gisa, Luca Gerardo Giordak gidatuta. Ingeniaritza Biomedikoan graduatua da TECNUNen, eta Ingeniaritza Biomediko Konputazionaleko master bat du Pompeu Fabra Unibertsitatean. Bere doktoretza-ikerketan erradiofrekuentzia kardiakoaren bidezko ablazioaren eta tronbosi goiztiarraren modelizazio konputazionala egiten du, ingurune jarraituan eta partikuletan oinarritutako ikuspegiak konbinatuz, ehun batek fluxu azpiko ablazioari eta odol koagulazioari ematen dion erantzuna aztertzeko. Ikerketa-egonaldiak egin ditu Linzeko KTH Royal Institute of Technology institutuan (Stockholm) eta Johann Radon Institut institutuan (RICAM). Ikerketa-lanarekin batera, doktoretzan bi seme-alaba izan ditu.

“Mathematical Modeling and Computational Simulation of Radiofrequency Ablation and Coagulation Processes” izeneko tesia Marco Ellero irakasleak (BCAM eta Ikerbasque) eta Luca Gerardo-Giorda irakasleak (Johann Radon Institut (RICAM)), Linz, zuzendu dute. Defentsa 2026ko irailaren 14an egingo da, Leioako Zientzia eta Teknologia Fakultateko Adela Moyua Aretoan, 11:30ean.

BCAMeko kide guztien izenean, etorkizunerako onena opa nahi dizugu, bai arlo profesionalean bai pertsonalean.

Abstract
Cardiac radiofrequency catheter ablation is a widely used treatment for cardiac arrhythmias. Although the procedure is generally effective, complications such as thrombus formation may occur during or after the intervention. Thrombosis near the ablation catheter can result from the combined effects of thermal tissue injury, biochemical activation and altered blood flow, motivating the development of computational approaches to better understand these processes.
This thesis develops two complementary computational frameworks to study different aspects of this problem. The first part presents a continuum-scale finite element model of radiofrequency ablation (RFA) that accounts for tissue deformation, electrical conduction and heat transfer. The model is used to investigate catheter-tissue mechanical interaction, temperature distributions and lesion formation, including the comparison of different contact algorithms.
The second part investigates early blood coagulation at the mesoscopic scale using Smoothed Dissipative Particle Dynamics (SDPD). Reduced models of the intrinsic and extrinsic coagulation pathways are coupled with diffusion and flow in idealised microvascular geometries. This framework allows the spatial transport and reaction of coagulation species to be resolved and is used to investigate how flow, geometry and localised biochemical activation influence thrombin and fibrin formation during early clot initiation.
The two modelling approaches are developed separately but are conceptually connected through the broader problem of thrombus formation in the context of cardiac RFA. They also provide a basis for future work towards integrating the different physical and biochemical processes involved.